Anti-Podocalyxin (PODXL or gp135) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.
Podocalyxin, a sialoglycoprotein, is a member of the sialomucin protein family and encoded by the PODXL gene in human. Podocalyxin is the major constituent of the glycocalyx of podocytes in the glomerulus. It coats the secondary foot processes of the podocytes. It is negatively charged and thus functions to keep adjacent foot processes separated, thereby keeping the urinary filtration barrier open.
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