Anti-ZO-3 (Tjp3) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Zonula occludens-3 (ZO-3), also known as tight junction protein-3 (TJP3) is a 100-kD tight junction peripheral protein encoded by the TJP3 gene in human. ZO-3 contains three PDZ domains, an SRC homology 3 (SH3) domain, and a yeast guanylate kinase homology (GUK) domain. ZO-3 can interact with tight junction integral proteins such as claudins and occludin, as well as ZO-1 and ZO-2.
ZO-3 is expressed in a variety of epithelial tissues including the kidney, the intestines, the lung, the liver, the pancreas and more.
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