Anti-Claudin-19 (CLDN19) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Claudin-19 is a protein that is encoded by the CLDN19 gene. It belongs to the claudin protein family making the tight junction in mammalian cells.
Tight junctions are intercellular organelles that form continuous seals around the epithelial or the endothelial cells to prevent solutes and water from diffusing into the paracellular space.
Mutations in CLDN19 gene cause a hereditary renal disease known as familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) and ocular involvement. Claudin-19 proteins are mostly found in the thick ascending limb of the kidney, in the pigment epithelium of the retina, and in the myelin made by the Schwann cell.
Published article used this antibody: Marneros, A.G. Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron. Cell Reports. 2021. 34:108616.
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