Anti-SOX2 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is encoded by the SOX2 gene in human. Sox2 plays a critical role in maintenance of embryonic and neural stem cells. LIF (Leukemia inhibitory factor) signaling, which maintains pluripotency in mouse embryonic stem cells, activates Sox2 downstream of the JAK-STAT signaling pathway and subsequent activation of Klf4 (a member of the family of Kruppel-like factors). Oct-4, Sox2 and Nanog positively regulate transcription of all pluripotency circuitry proteins in the LIF pathway.
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