Anti-Toll-like receptor 8 (TLR8 or CD288) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.
Toll-like receptor (TLR) family proteins play a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to human and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Toll-like receptor 8 (TLR8 or CD288) is a member of the TLR family that is encoded by the TLR8 gene in human. TLR8 is an endosomal receptor that recognizes single stranded RNA (ssRNA), and can recognize ssRNA viruses such as Influenza, Sendai, and Coxsackie B viruses. TLR8 binding to the viral RNA recruits MyD88 and leads to activation of the transcription factor NF-κB as a part of antiviral response.
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