Anti-Toll-like receptor 9 (TLR9 or CD289) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.
Toll-like receptor (TLR) family proteins play a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to human and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Toll-like receptor 9 (TLR9 or CD289) is a member of the TLR family that is encoded by the TLR9 gene in human. TLR9 preferentially binds to DNA present in bacteria and viruses, and triggers signaling cascades that lead to a pro-inflammatory cytokine response. TLR9 is also an important factor causing autoimmune diseases.
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