Anti-NKCC2 (Slc12a1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent tissues.
The Na-K-Cl cotransporter type 2 (NKCC2) protein is encoded by the SLC12A1 gene in human. NKCC2 is a kidney-specific Na-K-Cl cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle’s loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide.
NKCC2 consists in 12 transmembrane domains and the stoichiometry of the transported solutes is 1Na:1K:2Cl. Mutations in NKCC2 cause Bartter syndrome (OMIM 600839), which features low blood pressure, hypokalemic metabolic alkalosis, hypomagnesemia and hypercalciuria.
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