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KCNJ10 (Kir4.1 or SeSAME) antibody


Item Cat No.: 20210

Antibody: Rabbit KCNJ10 (Kir4.1 or SeSAME) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat


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Anti-KCNJ10 (Kir4.1 or SeSAME) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

KCNJ10, standing for inwardly-rectifying potassium channel, subfamily J, member 10, is an ATP-dependent potassium channel. It is encoded by the KCNJ10 gene in human. KCNJ10 is also known as Kir4.1 or SeSAME.

KCNJ10 consists in three transmembrane domains and the pore forming motif is within the 2nd transmembrane domain. ROMK is highly expressed by the Stria vascularis in the inner ear and the distal convoluted tubules in the kidney.

Mutations in KCNJ10 cause au autosomal recessive disease known as EAST syndrome or SeSAME syndrome (OMIM 612780), which includes seizure, sensorineural deafness, ataxia, mental retardation and electrolyte imbalances.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (19-aa) derived from the C-terminal region of human KCNJ10 protein

Species homology of immunogen: Synthetic peptide sequence is identical to mouse or rat sequence

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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