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CELSR1 (CDHF9 or FMI2) antibody

$125.00$375.00

Item Cat No.: 50801

Antibody: Rabbit CELSR1 (CDHF9 or FMI2) polyclonal antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat

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Anti-CELSR1 (CDHF9 or FMI2) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1), also known as flamingo homologue 2 (FMI2) or cadherin family member 9 (CDHF9) is encoded by the CELSR1 gene in human.

CELSR1 is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins, a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their extracellular domains. They also have seven transmembrane domains, a characteristic unique to this subfamily.

Flamingo was originally identified as a Drosophila protein involved in planar cell polarity. Flamingo belongs to the adhesion-GPCR family of proteins. Mammals have three flamingo homologues, CELSR1, CELSR2, and CELSR3. In Drosophila, flamingo mutants have defects including abnormal dendrite branching, outgrowth, and routing.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (13-aa) derived from the C-terminal region of mouse CELSR1 protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 92.3% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C


For Research Use Only. Not for use in clinical diagnostics.

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