Anti-N-cadherin (Cdh2 or CD325) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
N-cadherin is a protein that is encoded by the Cdh2 gene in human. N-cadherin is also known as Cadherin-2 or neural cadherin (NCAD) or CD325. N-cadherin belongs to the classic cadherin protein superfamily.
The cadherin protein features an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The cadherin ectodomain plays an adhesive role whereas the intracellular domain mediates cadherin-catenin interactions.
E-cadherin is widely expressed in tissues of mesoderm origin. Note that N-cadherin has high sequence similarity to E-cadherin (Cadherin-1). This antibody is developed using an N-cadherin specific sequence.
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