The conformational changes in a protein correspond to its vital function, such as an enzyme after binding to its substrate, a receptor after binding to its ligand, or an ion channel after binding to its blocker. Addressing the conformational change is, however, difficult owing to a lack of diagnostic tool.
BiCell Scientific Inc has developed a novel fixation and stabilization technique to lock the conformational state of a target protein. BiCell Scientific Inc is able to raise polyclonal and monoclonal antibodies against the target protein in its specific conformation state. BiCell Scientific Inc has introduced depletion chromatography technique with affinity columns conjugated to the target protein in different conformational states, e.g. ligand unbound receptor, to remove unwanted bindings of antibody as an additional measure to ensure conformational specificity toward ligand bound receptor.
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