RNA interference (RNAi) is a biological process in which a small fragment of double-stranded RNA (dsRNA) molecule (19-22 nt long) exerts sequence-specific suppression of gene expression, known as gene silencing. The dsRNA can be designed and expressed as a short-hairpin RNA (shRNA) by the type III RNA polymerase promoter, e.g. snRNP U6, in eukaryotic cells.
BiCell Scientific’s RNA interference service provides customized shRNA design, cloning and packaging services into retrovirus or lentivirus. The pre-packaged and ready-to-use retrovirus or lentivirus can infect a variety of mammalian cells to induce shRNA sequence-dependent gene silencing.
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