Anti-FAT2 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Protocadherin FAT2 is a protein that is encoded by the FAT2 gene in human. This gene is an orthologue of the Drosophila fat gene. FAT is involved in establishing the planar polarity in Drosophila cells.
Like classic cadherins, protocadherin proteins contain an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. Compared to classic cadherins, the ectodomains in protocadherins are much larger.
FAT2 is highly expressed in the retina, including the photoreceptor cells and the bipolar cells.
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