Anti-Integrin alpha-6 (ITGA6) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Integrins are transmembrane proteins that facilitate cell-extracellular matrix interactions or focal adhesions. Ligands for Integrins include fibronectin, vitronectin, collagen and laminin. An integrin molecule is composed of two protein subunits, alpha and beta. Each subunit consists in an extracellular domain, a single transmembrane domain and a cytoplasmic domain.
Integrin alpha-6 protein is encoded by the ITGA6 gene in human. Integrin alpha-6 is also known as CD49f or VLA-6.
Integrin alpha-6 subunit may interact with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family.
Integrin alpha-6 has many splicing forms. This antibody is raised against the canonical sequence of Integrin alpha-6 (Uniprot #P23229). It does not bind to the alternatively spliced isoform that has a different C-terminus sequence.
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