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KCNA4 (Kv1.4) antibody


Item Cat No.: 20224

Antibody: Rabbit KCNA4 (Kv1.4) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat


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Anti-KCNA4 (Kv1.4) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Potassium voltage-gated channel subfamily A member 4 (KCNA4), also known as Kv1.4, is a shaker related voltage-gated potassium channel that is encoded by the KCNA4 gene in human. Kv1.4 consists in six membrane-spanning domains with a shaker-type repeat in the fourth segment. Kv1.4 contains a tandem inactivation domain (1 and 2) at the N terminus. Inactivation domain 1 (ID1, residues 1-38) consists of a flexible N terminus anchored at a 5-turn helix, and is thought to work by occluding the ion pathway. Inactivation domain 2 (ID2, residues 40-50) is a 2.5 turn helix with a high proportion of hydrophobic residues that serves to attach ID1 to the cytoplasmic face of the channel.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (14-aa) derived from the C-terminal region of human Kv1.4 protein

Species homology of immunogen: Synthetic peptide sequence is identical to mouse or rat sequence

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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