Anti-KDM2B (JHDM1B) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.
Lysine (K)-specific demethylase 2B (KDM2B), also known as JmjC-domain-containing histone demethylase 1B (JHDM1B), is encoded by the KDM2B gene in human. KDM2B consists in a JmjC domain that has a histone demethylase activity demethylating trimethylated Lys-4 and dimethylated Lys-36 of histone H3. KDM2B specifically recognizes and binds non-methylated DNA in CpG islands through its ZF-CxxC DNA binding domain. KDM2B is present in the nucleoplasm and is enriched in the nucleolus where it binds the transcribed region of ribosomal RNA to represses the transcription of ribosomal RNA genes.
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