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NKCC2 (Slc12a1) antibody


Item Cat No.: 20301

Antibody: Rabbit NKCC2 (Slc12a1) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Mouse, rat


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Anti-NKCC2 (Slc12a1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent tissues.

The Na-K-Cl cotransporter type 2 (NKCC2) protein is encoded by the SLC12A1 gene in human. NKCC2 is a kidney-specific Na-K-Cl cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle’s loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide.

NKCC2 consists in 12 transmembrane domains and the stoichiometry of the transported solutes is 1Na:1K:2Cl. Mutations in NKCC2 cause Bartter syndrome (OMIM 600839), which features low blood pressure, hypokalemic metabolic alkalosis, hypomagnesemia and hypercalciuria.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (17-aa) derived from the N-terminal region of mouse NKCC2 protein

Species homology of immunogen: Synthetic peptide sequence is identical to rat sequence (showing 35.3% homology to human sequence)

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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