Anti-NOTCH2 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands establishes an intercellular signaling pathway that plays a key role in development.
Neurogenic locus notch homolog protein 2 (Notch 2) is a type-1 transmembrane protein that is encoded by the NOTCH2 gene in human. Mutations within the last coding exon of Notch2 that remove the PEST domain and escape the nonsense-mediated mRNA decay have been shown to be the main cause of the Hajdu-Cheney syndrome.
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