Anti-AGTR1 (AT1) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Angiotensin-II receptors (type 1 and type 2) are a class of G protein-coupled receptors with angiotensin-II as their ligands. They play a role of signal transduction in the renin-angiotensin system to mediate the effect of vasoconstriction of angiotensin-II.
The type 1 of angiotensin-II receptor, also known as AT1 or AGTR1, is encoded by the AGTR1 gene in human. The AGTR1 protein contains seven transmembrane domains and multiple extracellular and intracellular domains.
AGTR1 is expressed by the heart, blood vessels, kidney, adrenal cortex, lung and brain to mediate the vasoconstriction effects.
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