Anti-Piezo1 (C-terminus) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.
Piezo-type mechanosensitive ion channel component 1, abbreviated for Piezo1, is encoded by the PIEZO1 gene in human. Piezo1 is the pore-forming subunit of a mechanosensitive nonspecific cation channel, which generates electric currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium.
Piezo1 is a large membrane protein containing 36 transmembrane domains. Piezo1 plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Piezo1 also plays a key role in epithelial cell adhesion by maintaining integrin activation through the R-Ras signaling pathway. Mutations in PIEZO1 have been associated with dehydrated hereditary stomatocytosis in man.
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