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Piezo1 (C-terminus) antibody

$135.00$405.00

Item Cat No.: 20700c

Antibody: Rat Piezo1 Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat

Anti-Piezo1 (C-terminus) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

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Anti-Piezo1 (C-terminus) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

Piezo-type mechanosensitive ion channel component 1, abbreviated for Piezo1, is encoded by the PIEZO1 gene in human. Piezo1 is the pore-forming subunit of a mechanosensitive nonspecific cation channel, which generates electric currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium.

Piezo1 is a large membrane protein containing 36 transmembrane domains. Piezo1 plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Piezo1 also plays a key role in epithelial cell adhesion by maintaining integrin activation through the R-Ras signaling pathway. Mutations in PIEZO1 have been associated with dehydrated hereditary stomatocytosis in man.

Host/Isotype: Rat/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (12-aa) derived from the C-terminal cytoplasmic region of human Piezo1 protein

Species homology of immunogen: Synthetic peptide sequence is identical to mouse or rat sequence

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C


For Research Use Only. Not for use in clinical diagnostics.

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"I am really impressed with your approach. We tried multiple times previously to create monoclonal and polyclonal antibodies to claudin-2 and MLCK1. We have had limited success generating polyclonals and no success generating monoclonals. You have generated outstanding monoclonals to both. I look forward to continuing to work with you."

Jerrold R. Turner, M.D., Ph.D.

Brigham and Women’s Hospital | Harvard Medical School

"The polyclonal antibody you generated for KIAA0408 is stunning! KIAA0408 is a novel cilium molecule that has never been studied. So, clearly there will be a lot of demand for it as we have discovered a very interesting finding and the story will be published in a high impact journal. I am strongly inclined to generate monoclonal antibody for this protein too and we should think about patenting it."

Univ.-Prof. Jay Gopalakrishnan PhD

Heinrich-Heine-Universität | Universitätsklinikum Düsseldorf

"Your ARL13B antibody works beautifully!!! We’re so happy to have a cilia-specific antibody made in rat! I can send you high resolution images to be posted on your website."

Julie Craft Van De Weghe, PhD

School of Medicine | University of Washington

"The assay is a homophilic interaction mediated cell adhesion on purified protein (in this case, immobilized purified Pcdhga9 to Pcdhga9 expressed on cell surface). Compared to control, cell adhesion is reduced in the presence of Pcdhga9 monoclonal antibody supernatants!"

Divyesh Joshi, PhD

School of Medicine | Yale University

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