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Plakoglobin (gamma-catenin or JUP) antibody labeling of mouse tissue

Plakoglobin (gamma-catenin or JUP) antibody labeling of the developing skin

Plakoglobin proteins are found in the desmosomes of the skin from an embryonic mouse at E15.5.

Plakoglobin (gamma-catenin or JUP) antibody

$155.00 – $435.00

Item Cat No.: 00191

Antibody: Rabbit Plakoglobin (gamma-catenin or JUP) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat

Anti-Plakoglobin (gamma-catenin or JUP) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

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Anti-Plakoglobin (gamma-catenin or JUP) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Plakoglobin, also known as gamma-catenin, is encoded by the JUP gene in human. Plakoglobin consists in 12 armadillo repeats with N-terminal and C-terminal globular domains.

Plakoglobin is a major peripheral protein of the desmosome and the adherens junction. It links cadherins to the actin cytoskeleton. Although plakoglobin localizes to desmosomes and adherens junctions, its affinity for desmosomal cadherins is several times greater than for E-cadherin.

Plakoglobin is also localized at the intercalated disc of the cardiomyocyte, where it plays an essential role in stabilizing the cardiac muscle.

 

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (16-aa) derived from the C-terminal region of human Plakoglobin protein

Species homology of immunogen: Synthetic peptide sequence is identical to mouse or rat sequence

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

Protocol for Staining Desmosome Protein

General and Specific Protocols

Materials and reagents Expand Equipment Leica CM1950 automatic sectioning cryostat.Thermo Fisher Scientific round (12 mm diameter) cover glass (thickness No 1.5).Thermo Fisher Scientific ColorFrostTM Plus slides made of positively charge uncoated glass.   Tissue-tek Expand Tissue-tek OCT 4583 compound from VWR.Tissue-tek cryomolds from VWR. Buffers Expand BLOCK Solution  NaCl 8 gKCl 0.2 gNa2HPO4 1.44 gKH2PO4 […]

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Protocol for Staining Catenin

General and Specific Protocols

Materials and reagents Expand Equipment Leica CM1950 automatic sectioning cryostat. Thermo Fisher Scientific round (12 mm diameter) cover glass (thickness No 1.5). Thermo Fisher Scientific ColorFrostTM Plus slides made of positively charge uncoated glass.   Tissue-tek Expand Tissue-tek OCT 4583 compound from VWR. Tissue-tek cryomolds from VWR. Buffers Expand BLOCK Solution  NaCl 8 g KCl […]

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I have tested the rat polyclonal IgGs to ABCD1 by immunoflourescence on cells overexpressing ABCD1. The antibodies successfully detected the protein (either untagged or tagged with GFP) at a 1:500 dilution and there was little background. The antibodies did not detect ABCD2. So this is very good news, and you may now go ahead and clone out a monoclonal!

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