Anti-Plakoglobin (gamma-catenin or JUP) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Plakoglobin, also known as gamma-catenin, is encoded by the JUP gene in human. Plakoglobin consists in 12 armadillo repeats with N-terminal and C-terminal globular domains.
Plakoglobin is a major peripheral protein of the desmosome and the adherens junction. It links cadherins to the actin cytoskeleton. Although plakoglobin localizes to desmosomes and adherens junctions, its affinity for desmosomal cadherins is several times greater than for E-cadherin.
Plakoglobin is also localized at the intercalated disc of the cardiomyocyte, where it plays an essential role in stabilizing the cardiac muscle.
Reviews
There are no reviews yet.