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Polycystin-2 (PKD2) antibody

$99.00$295.00

Item Cat No.: 90502

Antibody: Rabbit Anti-Polycystin-2 (PKD2) Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat

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Anti-Polycystin-2 (PKD2) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Polycystin-2, also known as Transient receptor potential polycystin-2 cation channel (TRPP2), is encoded by the PKD2 gene in human. Polycystin-2 contains a N-terminal extracellular region, six transmembrane domains and a cytoplasmic C-tail. Polycystin-2 functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in a variety of epithelial cells. Polycystin-2 interacts with polycystin-1 and TRPC1.

Polycystin-2 plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 2 (ADPKD2) (OMIM 613095).

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (18-aa) derived from the C-terminal cytoplasmic region of human Polycystin-2 protein

Species homology of immunogen: Synthetic peptide sequence is identical to mouse or rat sequence

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C


For Research Use Only. Not for use in clinical diagnostics.

Protocol for Staining Primary Cilium (embryo section)

Materials and reagents Expand Equipment Leica CM1950 automatic sectioning cryostat.Thermo Fisher Scientific round (12 mm diameter) cover glass (thickness No 1.5).Thermo Fisher Scientific ColorFrostTM Plus slides made of positively charge uncoated glass.   Tissue-tek Expand Tissue-tek OCT 4583 compound from VWR.Tissue-tek cryomolds from VWR. Buffers Expand BLOCK Solution  NaCl 8 gKCl 0.2 gNa2HPO4 1.44 gKH2PO4 […]

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Protocol for Staining Primary Cilium (retina section)

Materials and reagents Expand Equipment Leica CM1950 automatic sectioning cryostat. Thermo Fisher Scientific round (12 mm diameter) cover glass (thickness No 1.5). Thermo Fisher Scientific ColorFrostTM Plus slides made of positively charge uncoated glass.   Tissue-tek Expand Tissue-tek OCT 4583 compound from VWR. Tissue-tek cryomolds from VWR. Buffers Expand 0.5% paraformaldehyde in PBS NaCl 8 […]

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