Anti-STK4 (MST1) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Serine/threonine kinase 4 (STK4), also known as MST1, is encoded by the STK4 gene in human. STK4/MST1 is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. STK4/MST1 is part of the Hippo signaling pathway. The Hippo signaling pathway comprises of a kinase cascade wherein MST1/2 phosphorylates and activates LATS1/2, which in turn phosphorylates but inactivates YAP and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
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