Anti-WWTR1 (TAZ) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
WW domain containing transcription regulator 1 (WWTR1), also known as TAZ, is encoded by the WWTR1 gene in human. WWTR1 is a transcriptional coactivator that acts as a downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway comprises of a kinase cascade wherein MST1/2 phosphorylates and activates LATS1/2, which in turn phosphorylates but inactivates YAP and WWTR1/TAZ. WWTR1 enhances PAX8 and TTF1-dependent gene transcription.
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