ACE2 antibody

Anti-ACE2 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

Angiotensin-converting enzyme 2 (ACE2) is an enzyme that is encoded by the ACE2 gene in human. ACE2 is a single-pass type I membrane protein. The extracellular domain of ACE2 can be cleaved from the transmembrane domain by ADAM17. The resulting cleaved protein is known as soluble ACE2 or sACE2. sACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1–7) (a vasodilator). sACE2 counters the activity of the related angiotensin-converting enzyme 1 (ACE1) by reducing the amount of angiotensin-II and increasing angiotensin (1-7).

ACE2 also serves as the receptor for some coronaviruses, including HCoV-NL63, SARS-CoV, and SARS-CoV-2 (Covid-19). The SARS-CoV-2 spike protein itself is known to damage the epithelium via downregulation of ACE2.

This antibody was raised against the extracellular domain of ACE2 and can recognize both soluble and membrane bound ACE2.