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ACE2 antibody

$125.00$375.00

Item Cat No.: 50410

Antibody: Rat ACE2 Polyclonal Antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat

Anti-ACE2 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

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Anti-ACE2 antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

Angiotensin-converting enzyme 2 (ACE2) is an enzyme that is encoded by the ACE2 gene in human. ACE2 is a single-pass type I membrane protein. The extracellular domain of ACE2 can be cleaved from the transmembrane domain by ADAM17. The resulting cleaved protein is known as soluble ACE2 or sACE2. sACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1–7) (a vasodilator). sACE2 counters the activity of the related angiotensin-converting enzyme 1 (ACE1) by reducing the amount of angiotensin-II and increasing angiotensin (1-7).

ACE2 also serves as the receptor for some coronaviruses, including HCoV-NL63, SARS-CoV, and SARS-CoV-2 (Covid-19). The SARS-CoV-2 spike protein itself is known to damage the epithelium via downregulation of ACE2.

This antibody was raised against the extracellular domain of ACE2 and can recognize both soluble and membrane bound ACE2.

Host/Isotype: Rat/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (15-aa) derived from the N-terminal extracellular region of human ACE2 protein

Species homology of immunogen: Synthetic peptide sequence is identical to mouse or rat sequence

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C


For Research Use Only. Not for use in clinical diagnostics.

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"I am really impressed with your approach. We tried multiple times previously to create monoclonal and polyclonal antibodies to claudin-2 and MLCK1. We have had limited success generating polyclonals and no success generating monoclonals. You have generated outstanding monoclonals to both. I look forward to continuing to work with you."

Jerrold R. Turner, M.D., Ph.D.

Brigham and Women’s Hospital | Harvard Medical School

"The polyclonal antibody you generated for KIAA0408 is stunning! KIAA0408 is a novel cilium molecule that has never been studied. So, clearly there will be a lot of demand for it as we have discovered a very interesting finding and the story will be published in a high impact journal. I am strongly inclined to generate monoclonal antibody for this protein too and we should think about patenting it."

Univ.-Prof. Jay Gopalakrishnan PhD

Heinrich-Heine-Universität | Universitätsklinikum Düsseldorf

"Your ARL13B antibody works beautifully!!! We’re so happy to have a cilia-specific antibody made in rat! I can send you high resolution images to be posted on your website."

Julie Craft Van De Weghe, PhD

School of Medicine | University of Washington

"The assay is a homophilic interaction mediated cell adhesion on purified protein (in this case, immobilized purified Pcdhga9 to Pcdhga9 expressed on cell surface). Compared to control, cell adhesion is reduced in the presence of Pcdhga9 monoclonal antibody supernatants!"

Divyesh Joshi, PhD

School of Medicine | Yale University

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