Anti-CACNA1C (Cav1.2) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Calcium channel, voltage-dependent, L type, alpha 1C subunit (also known as Cav1.2) is a protein that is encoded by the CACNA1C gene in human. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Cav1.2 is widely expressed in the smooth muscle, pancreatic cells, fibroblasts, and neurons. In the heart, Cav1.2 mediates L-type currents, which causes calcium-induced calcium release from the ER Stores via ryanodine receptors.
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