Anti-CaSR antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
The Calcium-sensing receptor (CaSR) is encoded by the CASR gene in human. It is a G-protein coupled receptor that senses extracellular levels of calcium ions. CaSR couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis.
The CaSR protein consists in seven transmembrane domains and is highly expressed by the kidney and the parathyroid glands. Loss-of-function mutations in the CASR gene are a cause of familial hypocalciuric hypercalcemia (FHH; OMIM 145980). Gain-of-function mutations in CASR cause autosomal dominant hypocalcemia or Bartter syndrome type 5 (OMIM 601198).
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