Anti-Collagen alpha-4 (IV) (Col4a4) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Collagen, type IV, alpha-4 chain is a protein that is encoded by the COL4A4 gene in human. Type IV collagen is the major structural component of the glomerular basement membrane (GBM).
Type IV collagen is a triple helical oligomer formed by 3 alpha chain molecules. Type IV collagen is found in the ear, the eye, and the kidney.
Mutations in COL4A4 cause a hereditary renal disease known as Alport syndrome (OMIM 120131).
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