Anti-Laminin beta-2 (LAMB2) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Laminin subunit beta-2 is encoded by the LAMB2 gene in human. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of the basement membrane. Laminins are composed of 3 different chains: laminin alpha, beta and gamma and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains.

Laminin beta-2 is expressed in the basement membrane at the neuromuscular junctions and the glomerular basement membrane of the kidney podocytes. Mutations in LAMB2 cause Pierson syndrome (OMIM 609049), also known as nephrotic syndrome type 5 (NPHS5), which manifests as diffuse mesangial sclerosis and distinct ocular abnormalities, including microcoria and hypoplasia of the ciliary and pupillary muscles.