Anti-Connexin-40 (Cx40 or Gja5) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Connexins are the structural proteins making the gap junction. Each gap junction is composed of two hemichannels, or connexons, which consist of a hexameric assembly of connexin proteins.
Connexin-40 is encoded by the Gja5 gene in human. Connexin-40 is also known as gap junction protein alpha-5. Connexins have four transmembrane domains, two extracellular loops, amino- and carboxyl-terminal cytoplasmic domains, and a cytoplasmic turn motif.
Connexin-40 is exclusively expressed by the myocardial cells in the heart. Connexin-40 makes gap junctions in the intercalated discs to coordinate electrical activation of the cardiac muscle.
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