Anti-E-cadherin (Cdh1 or CD324) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
E-cadherin is a protein that is encoded by the Cdh1 gene in human. E-cadherin is also known as Cadherin-1 or CAM 120/80 or uvomorulin or CD324. E-cadherin belongs to the classic cadherin protein superfamily and may act as a tumor suppressor.
The cadherin protein features an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The cadherin ectodomain plays an adhesive role whereas the intracellular domain mediates cadherin-catenin interactions.
E-cadherin is widely expressed in tissues of epithelial origin. Note that E-cadherin has high sequence similarity to N-cadherin (Cadherin-2). This antibody is developed using an E-cadherin specific sequence.
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