Anti-Cullin-3 (Cul3) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Cullin-3 is a component of Cullin-RING E3 ubiquitin ligase (CRL) complex which is involved in protein ubiquitylation. Cullin-3 is encoded by the CUL3 gene in human.
Cullin-3 may regulate the proteasomal degradation of WNK1 and WNK4, thus regulating the renal excretion of salt and the extracellular fluid volume. Mutations in CUL3 cause a dominant form of pseudohypoaldosteronism type 2 (PHA-II), also known as Gordon syndrome (OMIM 614496).
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