Anti-Ednrb (ET-B) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Endothelin receptors are G-protein coupled receptors that bind to the ligands – endothelins, the 21 amino acid long peptides known to exert vasoconstricting effects. There are two major types of endothelin receptors – ET-A and ET-B.
ET-B, also known as Ednrb, is encoded by the EDNRB gene in human. ET-B is a membrane protein containing seven transmembrane domains. The binding Endothelin to ET-B leads to the release of nitric oxide, which can dilate the blood vessel to lower blood pressure.
ET-B has been found highly expressed by the epithelium lining the bronchiole in the lung.
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