Anti-FGFR3 (CD333) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Fibroblast growth factor receptor 3, also known as CD333, is a membrane protein that is encoded by the FGFR3 gene in human. The FGFR3 protein consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular domain of the protein interacts with fibroblast growth factors, triggering a cascade of downstream signals, thereby regulating mitogenesis and differentiation. FGFR3 plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
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