Anti-Frizzled-4 (FZD4) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Frizzled class receptor 4, Frizzled-4 is encoded by the FZD4 gene in human. Frizzled-4 is also known as CD344. Members of the Frizzled protein family are receptors for Wnt signaling ligands.
Frizzled-4 consists in a cysteine-rich N-terminal extracellular domain, seven transmembrane domains and a C-terminal PDZ domain binding motif.
Frizzled-4 is the only frizzled family member that binds to Norrin that is structurally different from Wingless type protein. Frizzled-4 signaling induced by Norrin regulates vascular development of the retina and the inner ear.
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