Anti-GABRB3 antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Gamma-aminobutyric acid type A (GABA-A) receptor subunit beta-3 is a protein that is encoded by the GABRB3 gene in human. GABA-A is the receptor protein that, once bound to its ligand, GABA, transmits inhibitory signals in the mammalian brain. GABA-A receptor protein functions as a ligand-gated chloride channel. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in GABRB3 are associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism.
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