Anti-GRIN2B (GluN2B) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Glutamate ionotropic receptor NMDA type subunit 2b (GRIN2B), also known as GluN2B, is encoded by the GRIN2B gene in human. GRIN2B is a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. NMDA receptors function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. NMDA receptors play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Mutations in the GRIN2B gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.
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