Insulin receptor (INSR or CD220) antibody

Anti-Insulin receptor (INSR or CD220) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from human and rodent tissues.

Insulin receptor, also known as CD220, is a transmembrane receptor that is encoded by the INSR gene in human. Insulin receptor is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, insulin receptor plays a key role in the regulation of glucose homeostasis. Insulin receptor is proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ~320 kDa disulfide-linked transmembrane insulin receptor.

Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome.