Anti-JAG1 (CD339) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands establishes an intercellular signaling pathway that plays a key role in development.
The jagged canonical Notch ligand 1 (JAG1) is encoded by the JAG1 gene and the homolog of the Drosophilia jagged protein in human. Jagged1 (JAG1) is a cell surface ligand protein that interacts with Notch receptors in the mammalian Notch signaling pathway. Mutations in the JAG1 gene cause Alagille syndrome.
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