Anti-Nephrocystin-4 (NPHP4) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Nephrocystin-4 is encoded by the Nphp4 gene in human. Nephrocystin-4 is considered as a primary cilium protein. It also participates in Hippo and planar polarity signaling pathways.
Nephrocystin-4 is a 157-kDa protein. Mutations in Nephrocystin-4 cause Senior-Loken syndrome 4 (SLSN4) (OMIM 606996) or nephronophthisis 4 (OMIM 606966), which is characterized by renal cyst formation and kidney fibrosis.
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