PDGFRB (CD140b) antibody

Anti-PDGFRB (CD140b) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

PDGFRB, platelet-derived growth factor receptor B, also termed PDGFRβ, or CD140b, Cluster of Differentiation 140b, is a tyrosine kinase receptor that is encoded by the PDGFRB gene in human. PDGFRB acts as a cell-surface receptor for PDGFA, PDGFB and PDGFD and plays an essential role in normal development of the cardiovascular system. PDGFRB consists of an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. A translocation between chromosomes 5 and 12, that fuses the PDGFRB gene to the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia.