Polycystin-1 (PKD1) monoclonal antibody (B2 clone)

Anti-Polycystin-1 (PKD1) monoclonal antibody (B2 clone) is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Polycystin-1, also known as Transient receptor potential polycystin-1 cation channel (TRPP1), is encoded by the PKD1 gene in human. Polycystin-1 contains a large N-terminal extracellular region, eleven transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways.

Polycystin-1 plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1) (OMIM 173900).