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YAP (YAP1) antibody


Item Cat No.: 50902

Antibody: Rabbit YAP (YAP1) polyclonal antibody

Concentration: 0.25 mg/ml purified IgG

Application: Validated by immunofluorescence labeling (1:100)

Reactivity: Human, mouse, rat


Optional Blocking Peptide

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Anti-YAP (YAP1) antibody is validated on mouse tissue and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.

Yes1 associated transcriptional regulator (YAP1 or YAP) is encoded by the YAP1 gene in human. YAP is a transcriptional factor of the Hippo signaling pathway which is involved in tissue development, growth, repair, and homeostasis. The Hippo signaling pathway comprises of a kinase cascade wherein MST1/2 phosphorylates and activates LATS1/2, which in turn phosphorylates but inactivates YAP and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.

Host/Isotype: Rabbit/IgG

Class: Polyclonal

Immunogen: Synthetic peptide (19-aa) derived from the C-terminal region of human YAP1 protein

Species homology of immunogen: Synthetic peptide sequence is identical to mouse or rat sequence

Conjugation: Unconjugated

Purification: Affinity chromatography

Storage buffer: PBS, pH 7.2, 0.1% sodium azide

Storage condition: –20°C

For Research Use Only. Not for use in clinical diagnostics.

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